binding of naproxen to serum proteins in patients with liver cirrhosis and healthy individuals

نویسندگان

eugene j kucharz from the fourth department of internal medicine, silesian university school of medicine, ul. edukacji 102, pl 43- 100 tychy, poland.

چکیده

a three-fold decrease of the in vitro ability of serum proteins to bind naproxen was shown in patients with cirrhosis of the liver compared to healthy individuals. this decrease was caused by quantitative changes in serum proteins in the sera of patients with liver damage. lower doses of naproxen are therefore suggested in the treatment of patients with liver dysfunction.

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BINDING OF NAPROXEN TO SERUM PROTEINS IN PATIENTS WITH LIVER CIRRHOSIS AND HEALTHY INDIVIDUALS

A three-fold decrease of the in vitro ability of serum proteins to bind naproxen was shown in patients with cirrhosis of the liver compared to healthy individuals. This decrease was caused by quantitative changes in serum proteins in the sera of patients with liver damage. Lower doses of naproxen are therefore suggested in the treatment of patients with liver dysfunction.

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عنوان ژورنال:
medical journal of islamic republic of iran

جلد ۹، شماره ۳، صفحات ۲۱۷-۲۱۹

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